Ossobuco with Polenta My Way Lena Ossobuco is a dish loved by Italians, and everyone has their own way of preparing it. I like to prepare it in my own way, and it is a little different from the original, but I think mine is even better and tastier. You can make Ossobuco in several ways, depending on the region of Italy itself. Ossobuco is a piece of beef in the thigh on the shin, from which the typical Milanese dish originates. I love making it so much! Follow the recipe. Ing